中国老年非霍奇金淋巴瘤患者年龄界值的探讨

Prognostic Differences among Different Age Limits in Chinese Elderly Patients with Non-Hodgkin's Lymphoma

目的探讨适合我国老年非霍奇金淋巴瘤（NHL）患者的年龄界值。方法回顾性分析北京协和医院1990年1月-2007年12月收治的病例资料较完整的507例NHL患者的临床资料,并对所有病例进行电话随访,随访截止日期为2008年10月。结果小于60岁、60-64岁、65-69岁、70-74岁和大于75岁年龄组患者的5年生存率分别为64.6%、53.0%、32.8%、40.0%和19.8%,8年生存率分别为45.7%、44.1%、17.5%、22.8%和0。75岁以上组与65-70岁组、60-65岁组和60岁以下组,65-70岁组与60岁以下组间的生存率差异均有统计学意义（P均〈0.05）。多因素回归分析显示,年龄、血清白蛋白水平和血红蛋白水平对患者生存状态有影响。结论可以考虑将65岁作为老年NHL患者的年龄界值。

Objective To explore the feasible age limits in Chinese elderly patients with non- Hodgkin＇s lymphoma （NHL）. Methods The clinical data of 507 patients with NHL who were admitted to Peking Union Medical College Hospital （PUMCH） from January 1990 to December 2007 were retrospectively analyzed. They were further followed up by reviewing medical records or by phone. The deadline of follow-up was October 2008. Results The 5-year/8-year overall survival （OS） rates were 64. 6%/45.7%, 53.0%/ 44.1%, 32.8%/17.5%, 40. 0%/22.8%, and 19.8%/0, respectively, in patients aged 〈60 years, 60- 64 years, 65-69 years, 70-74 years, and ≥75 years. The OS rate was significantly different between patients aged ≥75 years and other age groups, and between patients aged 65-70 years and patients younger than 60 years （ P 〈 0.05 ）. Only age, serum albumin, and hemoglobin affected the survival status in elderly NHL patients. Conclusion Sixty-five years can be regarded as the age limit in Chinese NHL patients.