男性乳腺癌41例临床诊治分析

Diagnosis and treatment of male breast cancer:an analysis of 41 cases

目的探讨男性乳腺癌(MBC)的诊治经验。方法回顾性总结长海医院21年间收治的41例男性乳腺癌患者的临床资料;分析临床及病理因素与生存率的关系。40例接受手术治疗,其中根治术11例,改良根治术25例,单纯乳腺切除术4例。结果临床TNM分期Ⅰ,Ⅱ,Ⅲ,Ⅳ期分别为8,19,11,3例。除2例失访外,其余39例(95.1%)随访1～20年(中位7.2年),5年生存率为65.9%。其中单纯乳腺切除术,改良根治术,根治术的5年生存率分别为25%,72%和72.7%。结论改良根治术为MBC首选手术方式,手术方式、腋窝淋巴结情况、病理分期、病理类型及ER情况等因素影响预后。

Objective To summarize our experience in the diagnosis and treatment of male breast cancer （MBC）. Methods A total of 41 patients with MBC treated in our hospital from 1985 -2006 were analyzed restrospectively. Forty patients underwent surgery, including radical mastectomy （ 11 cases ） , modified radical mastectomy （ 25 cases ） , and simple mastectomy （ 4 cases ） . Results Clinical TNM stage of the cancer was stage I （Scases） ,stage I] （19 cases） ,stage m （11 cases）and stage IV（3 cases）. The median follow-up period was 7.2 years （ range, 1 - 20 years ） , and the follow-up rate was 95. 1% . The total 5-year overall survival was 65.9%. The 5-year survival after radical mastectomy, modified radical mastectomy, and simple mastectomy was 25%, 72% and 72. 7% respectively. Conclusions The modified radical mastectomy is the surgical method of first choice for MBC. The influential factors on prognosis of MBC include type of operative procedure, the status of axillary lymph node, TNM tumor stage, the pathological type and the ER status.