缬沙坦和非洛地平治疗Ⅰ、Ⅱ级高血压病的疗效对比观察

Comparetive Observation of Theraputic Effect of Valsartan and Felodipin in Treatment of Grade Ⅰ、Ⅱ Essential Hypertension

目的评价缬沙坦(Valsartan)治疗Ⅰ、Ⅱ级高血压病(EH)的临床疗效。方法选取Ⅰ、Ⅱ级高血压病(EH)患者[坐位舒张压90～109mmHg,收缩压140～179mmHg]共132例,随机分为两组,每组各66例。Ⅰ组为治疗组,给予缬沙坦80mg/d清晨口服;Ⅱ组为对照组,给予长效钙拮剂非洛地平(Felodipin)5mg/d清晨口服。在服药前及服药后2、4、6、8周末时对每位患者各测量血压一次。结果8周后,治疗组SBP/DBP下降(32.8±11.0/13.0±6.4)mmHg;对照组SBP/DBP下降(29.3±8.6/11.8±7.9)mmHg。两组间2、4、6、8周血压值无统计学意义(P>0.05),说明两药降压疗效相似。结论缬沙坦和非洛地平治疗Ⅰ、Ⅱ级高血压疗效确切、患者耐受性好、不良反应少,是治疗这类高血压的理想药物。

Objective To evaluate the efficacy of Valsartan and Felodipin treating the Chinese patients with mild to moderate essential hypertension. Methods Patients with mild to moderate essential hypertension [sitting diastolic blood pressure （SiDBP） of 90-109 mm Hg, systolic blood pressure （SiSBR） of 140-179 mm Hg]（n=132） were selected and derided into two groups by double-blind randomized study, Every group has 66 patients. The patients of treatment group were treated with Valsartan 80 mg/d and control group with Felodipin 5 mg/d for comparison of efficacy. All of the patients were treated for 6 weeks. Blood Pressure was examined before the treatment and at the end of 2,4,6,8 weeks. Results At the end of 8 weeks, no statistical difference was found in the antihypertensive effect between the two drugs （P〉0.05）. SiSBP/SiDBP in the treatment group were reduced by （32.8±11.0/13.0±6.4） mm·Hg by Valsartan and SiSBP/SiDBP in control group were lowered by （29.3±8.6/11.8±7.9） ram Hg by Felodipin. Conclusion Valsartan and Feloeipin were effective and well tolerated in Chinese patients with grade Ⅰ、Ⅱ essential hypertension with little side effect. Valsartan is a satisfactory drug in the treatment of hypertension.