伊达拉奉联合长春西汀治疗急性脑梗死的临床疗效观察

Clnical Effect of Edaravon combined with vinpocetine on the acute cerebfal infarction

目的评价自由基清除剂依达拉奉和长春西汀联合应用治疗急性脑梗死的临床疗效及安全性。方法选择临床确诊的急性脑梗死患者68例,随机分为2组:治疗组34例,给予伊达拉奉30mg加入生理盐水100ml静脉滴注,每日2次,连用14d;对照组34例,给予吡拉西坦100ml静脉滴注,每日2次,连用14d用;两组均予长春西汀30mg静脉滴注,每日1次;阿司匹林0.1每晚1次口服;治疗前后定期采用中国卒中量表(CSS)对神经功能缺损进行评定,采用Barthel指数记分对日常生活能力﹝ADL﹞进行评定,结果治疗组总有效率为88.2%,对照组为52.9%,治疗组疗效明显优于对照组,两组总有效率比较有显著性差异(P<0.01)结论依达拉奉和长春西汀联合应用能有效改善急性脑梗死的神经功能缺损和日常生活能力,疗效确切,无严重的不良反应。

Objectlve To evaluate the effect and adverse reactions of the combination of Edaravon and vinpocetine on treat acute cerebfal infarction （ACI）.Methods Select the clinical diagnosis of acute cerebral infarction in 68 patients were randomly divided into 2 groups： treatment group, 34 patients given Yida La Bong-30mg intravenously 2 times a day qd for 14 days; control group, 34 patients given imidacloprid Rasi Tan 100ml intravenous infusion 2 times a day, used in conjunction with the 14 days; the two groups are therefore correspondingly Vinpocetine 30mg intravenous infusion, daily one time; an oral dose of aspirin, 0.1 per night; before and after treatment on a regular basis using the Chinese Stroke Scale （CSS） on the neurological deficit were evaluated using Barthel ADL Scale （ADL） evaluated.Results The total effective rate of the treatment group was 88.2%, 52.9% in the control group, treatment group significantly better than the control group the two groups compared the total effective rate was significant difference （P 〈0. 01） Conclusion The combination of edaravone and vinpocetine in acute ischemic stroke can be effective in improving neurologic impairment and activities of daily living, curative effect, no serious adverse reactions.