摘要
目的探讨了乳腺癌患者手术治疗前后血清E-cad、CA153和VEGF水平的变化及临床意义。方法分别应用放射免疫分析法和酶免法对36例乳腺癌患者进行了手术治疗前后血清E-cad,CA153和VEGF水平检测,并与35名正常健康人作比较。结果手术前乳腺癌患者血清E-cad、CA153和VEGF水平均非常显著地的高于正常人组(P<0.01),手术治疗后1年复发组有明显地高于无复发组(P<0.01)。结论检测乳腺癌患者手术治疗前后血清E-cad、CA153和VEGF水平的变化与患者的病情和预后密切相关,具有重要的临床价值。
Objective To explore the clinical significance of changes of serum E-cad,CA153 and VEGF lenels after operation in patients with breast cancer. Methods Serum CA153 （with RIA）,Serum E-cad,VEGF （with Elisa） lenels were measured in 36 patients with beast cancer both before and after operation as well as in 35 contralso Results Before operation,Serum E-cad,CA153 and VEGF lenels were significantly higher in patients these in contrals （p〈0.01）. Twenty-six of the 32 patients under gone operative therapy showed no sign of recurrence at one year after operation and their serum E-cad, CAl53 and VEGF lenels dropped to with in normal range,however,in the 6 patients with recurrence,the serum lenels of E-cad,CA153 and VEGF remained abnormally high and were significantly higher than those in the patients without recurrence （p〈0.01）.Conclusions Serum E-cad , CA153 and VEGF process of breast cancer and were of prognostic Value.
出处
《医学信息》
2009年第12期2767-2769,共3页
Journal of Medical Information
关键词
乳腺癌
上皮性钙粘蛋白
糖类抗原-153
血管内皮生长因子
Breast cancer
E-cadherin.（E-CAD）
Carbohydrate antigen 153 （CA153）
Vascular endothelial growth factor （VEGF）
