氟喹诺酮类药物不良反应187例文献分析

Analysis of 187 ADR cases induced by Fluoroquinolones

目的探讨氟喹诺酮类药物不良反应发生的特点和一般规律。方法对2006年1月-2009年1月期间国内医药期刊报道的氟喹诺酮类药物致不良反应187例进行统计、分析。结果在年龄分布上差异无显著性;临床表现以过敏反应(占25.67%),消化系统反应占(20.86%),血糖波动(占17.11%),神经系统反应(占11.76%)为主;引起不良反应的药品种类主要有左氧氟沙星、加替沙星、培氟沙星、环丙沙星等。结论临床应重视氟喹诺酮类药物不良反应的监测工作,可减少或避免不良反应的重复发生。

Objective To discuss the general features and manifestations of adverse drug reactions（ ADR） induced by flouroquinolones（FQs）. Methods 187 ADR cases induced by flouroquinolones reported in domestic medical journals from January 2006 to January 2009 were statistically analyzed. Results There was no significant difference in terms of age distribution; allergic reactions accounted for 25.67%, Digesting system reactions accounted for 20.86%, blood glucose fluctuations accounted for 17. 11%,, nervous system reactions accounted for 11.76%. The ADR mainly induced by Levofloxacin、 Gatifloxacin 、Pefloxacin and Ciprofloxacin etc. Conclusions Great importance should be attached to monitoring on ADR induced by flouroquinolones,in order to reduce or avoid recurrence of ADR.