玉屏风散对咳嗽变异型哮喘缓解期患者免疫功能的影响

Effect of Yupingfeng Powder on Immune Function in Cough-variant Asthma Patients at Remission Stage

【目的】观察玉屏风散对咳嗽变异型哮喘(CVA)缓解期患者免疫球蛋白E(IgE)及T淋巴细胞亚群CD4+、CD8+等免疫功能的影响。【方法】将74例患者随机分为治疗组36例和对照组38例,治疗组予以玉屏风散口服(药物组成:黄芪、白术、防风),对照组予以安慰剂口服,连服8周。观察两组患者治疗前后血清IgE及外周血CD4+、CD8+的变化情况。【结果】治疗组治疗后IgE、CD4+水平显著降低(P<0.01),CD8+水平显著升高(P<0.01),CD4+/CD8+显著下降(P<0.01),而对照组治疗前后各项指标均无显著变化(P>0.05)。治疗后两组间比较,各项指标差异均有显著性意义(P<0.05或P<0.01)。【结论】玉屏风散可能通过调节T淋巴细胞亚群和降低血清IgE水平,从而抑制气道炎症,降低气道高反应性,增强人体抗病能力,改善CVA缓解期患者的免疫功能。

Objective To observe the effect of Yupingfeng Powder （YP） on IgE level and T lymphocyte subpopulations of CD4^＋ and CD8^＋ in cough-variant asthma patients at remission stage. Methods Seventy-four cough-variant asthma （CVA） patients at remission stage were randomized into two groups. The treatment group （N = 36） received oral use of YP and the control group （N = 38） received oral use of placebo, the treatment lasting 8 weeks. The changes of serum IgE level and T lymphocyte subpopulations of CD4^＋ and CD8^＋ were observed before and after treatment. Results After treatment, serum IgE level and CD4^＋ percentage were decreased, CD8^＋ percentage increased, and CD4^＋/CD8^＋ decreased in the treatment group （P 〈 0.01 compared with those before treatment）. The differences of the above parameters were insignificant in the control group before and after treatment （ P 〉 0. 05 ） , but were significant between the control group and the treatment group after treatment （P 〈 0.05 or P 〈 0. 01 ）. Conclusion YP can regulate T lymphocyte subpopulations and decrease serum IgE level, inhibit airway inflammation and decrease airway hyperreactivity, thus improve immune function.