脑卒中后抑郁与脑损伤部位关系的临床研究

Clinical Research of the Relationship Between Post-stroke Depression and the Region of Brain Injury

目的:探讨脑卒中后抑郁(PSD)与脑卒中病变部位之间的关系。方法:对175例脑卒中患者进行汉密尔顿抑郁量表(HAMD)评分,神经功能缺损评分,对发生卒中后抑郁的患者进行脑内病变部位的相关分析。结果:73例脑卒中患者合并PSD,总发生率41.71%,其中轻度抑郁22.29%,中度抑郁12.57%,重度抑郁6.85%;PSD发生与卒中类型无关,而与病变部位、神经功能缺损程度等因素有关。结论:PSD发生率高,脑器质性损伤的部位可能是其发生的生物学基础;神经功能缺损程度评分越高,其患抑郁的程度也就越高。

Objective：To explore the relationship between poststroke depression （PSD） and the region of brain injury. Methods： 175 patients with stroke were accessed by Hamilton Depression Scales （HAMD）. The chinese stroke clinical neurological impairment of scale score were used to measure the patients at the same time. To analyze the correlation between the PSD and the region of brain injury. Results： There are 73 cases with PSD in all the patients.The incidence rate is 41.71%. The minor, moderate and severe incidence were 22.29%, 12.57% ,6.85% respectively. The important factors involved the region of stroke, the degree of the neurological deficits and disabled in PSD. It had no relation with type of stroke. Conclusion：The incidence of depression was high in post - stroke patients. The region of brain injury may be one of the factors resulting in PSD. The higher neurological impairment score is, the deeper the degree of depression occurs.