RUNX3蛋白表达与宫颈癌临床病理学的关系及意义

Relationship and significance of RUNX3 expression and clinic pathology in cervix cancer

目的探讨RUNX3蛋白在宫颈癌组织中的表达及其临床意义。方法选取宫颈癌患者88例,以正常宫颈组织20例作为对照,应用SP免疫组化方法检测RUNX3蛋白的表达,分析其与宫颈癌的病理分级及临床分期的关系。结果宫颈癌组织中RUNX3阴性、弱、中、强表达依次为56.8%(50/88)、22.7%(20/88)、17.0%(15/88)、3.4%(3/88),与正常宫颈组织相比,RUNX3在宫颈癌的表达存在显著下调(P<0.01)。宫颈癌中RUNX3表达与肿瘤生长类型、FLGO分期、盆腔淋巴结转移、病理分级均密切相关(P<0.05)。结论RUNX3与宫颈癌的发生、浸润、转移有关,可作为新的宫颈癌标记物,具有重要的临床意义。

[ Objective ] To analyze the clinicopathological features of the expression of RUNX3 in human cervix cancer and evaluate its clinical significance in the progression of cervix cancer. [ Methods ] 88 patients with cervix cancer were examined for the expression of RUNX3 by SP immunohistochemistry. [Results] The negative, weak positive, moderate positive and strong positive expression rates of RUNX3 in 88 patients with the cervix cancer were 56.8% （50/88）, 22.7% （20/88）, 17.0% （15/88） and 3.4% （3/88）, respectively, which were significantly higher than those in 20 cases of normal cervix tissue （P 〈0.01）. The positive expression of RUNX3 in cancer tissues of the cervix was associated significantly with FIGO grading, metastasis staging and differentiation of cancer tissues （P 〈0.01）. [ Conclusion ] The results suggest that the expression of RUNX3 may be an important feature of cervix cancer.