谷氨酸诱导细胞凋亡的机制及对内毛细胞突触复合体的损伤
摘要
谷氨酸在中枢神经组织和内耳神经组织都是重要的兴奋性递质，其过量的释放可致兴奋毒性损伤。凋亡是谷氨酸致组织损伤的途径之一。其引起凋亡的机制包括线粒体途径和非线粒体途径。在内耳组织，过量的谷氨酸造成的兴奋毒性也可引起内毛细胞突触复合体的损伤，其具体的信号途径还需要进一步的探讨。
出处
《国际耳鼻咽喉头颈外科杂志》
2009年第6期325-327,共3页
International Journal of Otolaryngology-Head and Neck Surgery
基金
基金项目：国家自然科学基金资助项目（30872858）
教育部高校博士点基金支持项目（200800250006）
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