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神经生长因子与听觉系统 被引量：3

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摘要 自1948年神经生长因子（nerve growth factor，NGF）被Levi—Montalcini发现以来，因其重要的理论研究意义及现实的临床应用价值日益受到重视。本文主要对NGF及其受体在内耳的表达情况，以及近年来在听觉系统方面的实验研究作一综述。
作者 蔡琴芳 蒋立新
机构地区 暨南大学附属第一医院耳鼻咽喉头颈外科
出处 《国际耳鼻咽喉头颈外科杂志》 2009年第6期343-345,共3页 International Journal of Otolaryngology-Head and Neck Surgery
关键词 神经生长因子(Nerve Growth Factor) 听力 (Hearing) 耳蜗 (Cochlea)
分类号 R764 [医药卫生—耳鼻咽喉科]
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参考文献19

  • 1Despres G, Romand R. Presence of a nerve growth factor-like immunoreactivity in auditory receptors during postnatal development intherat. CRAcadSciIII, 1988, 306 (3) : 135-138.
  • 2Dai CF, Steyger PS, Wang ZM, et al. Expression of Trk A receptors in the mammalian inner ear. Hear Res, 2004, 187 (1- 2) : 1-11.
  • 3Frago LM, Canon S, de la Rosa EJ, et al. Programmed cell death in the developing inner ear is balanced by nerve growth factor and insulin-like growth factor I. J Cell Sci, 2003, 116 (Pt 3) : 475- 486.
  • 4Pirvola U, Ylikoski J, Palgi J, et al. Brain-derived neurotrophic factor and neurotrophin 3 mRNAs in the peripheral target fields of developing inner ear ganglia. Proc Natl Acad Sci USA, 1992, 89 (20) : 9915-9919.
  • 5Staecker H, Van De Water TR, Lefebvre PP, et al. NGF, BDNF and NT-3 play unique roles in the in vitro development and patterning of innervation of the mammalian inner ear. Brain Res Dev Brain Res, 1996, 92 (1):49-60.
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  • 8Zheng JL, Gao WQ. Differential damage to auditory neurons and hair cells by ototoxins and neuroprotection by specific neurotrophins in rat cochlear organotypic cultures. Eur J Neurosci, 1996, 8 (9) : 1897-1905.
  • 9Sobkowicz HM, August BK, Slapnick SM. Influence of neurotrophins on the synaptogenesis of inner hair cells in the deaf Bronx waltzer (bv) mouse organ of Corti in culture. Int J Dev Neurosci, 2002, 20 (7) :537-554.
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二级参考文献27

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共引文献20

同被引文献28

引证文献3

二级引证文献14

国际耳鼻咽喉头颈外科杂志
2009年 第6期

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