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EB病毒诱导基因3在Th细胞免疫反应中的作用

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摘要 EB病毒诱导基因3（epstein．Barrvirusinducedgene3，EBl3）是在EB病毒转化的B细胞培养上清液中发现的与细胞因子IL一12同源的可溶性细胞因子受体，在体内以同源二聚体、IL．27异源二聚体和IL一35异源二聚体3种形式存在。在免疫应答反应中，EBl3参与调节效应性T辅助细胞Thl、Th2和Thl7细胞的活化与分化，发挥抗感染和抗变应性炎症等调节作用。最近发现EBl3是调节性T细胞中Foxp3转录因子的下游靶分子，抑制调节性T细胞的分化和其免疫抑制活性，并与多种疾病的发病机制和免疫状态密切相关，是治疗感染性疾病、变应性疾病以及自身免疫性疾病的新靶点。
作者 欧阳昱晖 张罗 韩德民
机构地区 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科 耳鼻咽喉头颈科学教育部重点实验室(首都医科大学) 北京市耳鼻咽喉科研究所
出处 《国际耳鼻咽喉头颈外科杂志》 2009年第6期360-363,共4页 International Journal of Otolaryngology-Head and Neck Surgery
基金 基金项目：国家自然科学基金（30872846） 北京市自然科学基金资助项目（7072017） 通信作者：欧阳昱晖,Email：oyyuhui@hotmail.tom
关键词 基因 病毒(Genes Viral) 病毒激活(Virus Activation) CD4阳性T淋巴 细胞(CD4-Positive T-Lymphocytes) 白细胞介素类(Interleukins)
分类号 R392 [医药卫生—免疫学]
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参考文献23

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二级参考文献39

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国际耳鼻咽喉头颈外科杂志
2009年 第6期

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