摘要
目的:观察和评价双氯芬酸钠利多卡因用于胸外科开胸手术术后镇痛治疗的临床疗效和安全性。方法:以舒芬太尼为对照药,选择胸外科开胸手术患者160例,随机分为两组(n=80);观察组给药剂量为每次1支,75 mg/支,肌内注射,每日2次;对照组给药为静脉自控镇痛,剂量为:舒芬太尼1.0 mg+托烷司琼5 mg.(200 mL)-1。观察记录术后4、8、12、24、36、48、72各时点镇痛评分(VAS)和镇静评分(SS)及其间的不良反应情况。结果:两组镇痛评分(VAS)无显著的统计学差异(P>0.05),镇静评分(SS)有显著的统计学差异(P<0.05),试验组镇静效果及恶心、呕吐等不良反应明显低于对照组。结论:双氯芬酸钠利多卡因用于胸外科开胸术后镇痛治疗的效果优良,不良反应少,是一种安全、有效的术后镇痛方法。
OBJECTIVE： To evaluate the analgesic efficacy and safety of Diclofanac Sodiam/Lidocaine Hydrochloride Injection in patients after undergoing thoracotomy. METHODS： 160 patients who underwent thoracotomy were randomly divided into 2 groups （n = 80 each ）： the experimental group （intramuscular injection： Diclofanac Sodiam/Lidocaine Hydrochloride 75 mg, b. i. d） and the control group [ intravenous continuously analgesia： Sufentanyl 1.0 mg plus Tropisetron 5 mg·（200 mL）^-1]. Visual analog scale score （VAS） and sedation score （SS） were recorded at 4,8,12,24,36,48 and 72 hours after operation, meanwhile, the adverse drug reactions were observed. RESULTS： There were no significant differences in VAS scores between the two groups （ P 〉 0.05） ; however, significant differences were noted in sedation scores between the two groups （P 〈 0.05 ）. The sedative efficacy and the adverse drug reactions such as nausea and vomiting of the experimental group were significantly less than in control group. CONCLUSION： Intramuscular injection of Diclofanac Sodiam/Lidocaine Hydrochloride is proved to be a safe and effective postoperative analgesic therapy with good analgesic efficacy yet less adverse reactions.
出处
《中国医院用药评价与分析》
2009年第11期849-851,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
