阿奇霉素分散片的研制

Development of Azithromycin Dispersible Tablets

使用正交设计法，以聚乙烯吡咯烷酮、微晶纤维素和羧甲基淀粉钠用量为3因素，在3个水平上拟合，以崩解时限为指标，用L9（3^4）进行实验。并对优选处方制成品进行了溶出度测定。优选处方中聚乙烯吡咯烷酮为4％，微晶纤维素为37．5％，羧甲基淀粉钠为5％。所研制的阿奇霉素分散片崩解时限为57秒，3分钟时阿奇霉素的累积溶出达87％。研制的阿奇霉素分散片制备工艺可靠，溶出迅速。

We use the orthogonal experiment design by using L9（3^4）, take the disintegration time as a target, the dosages of PVP, microcrystalline cellulose, and CMS-Na as 3 factors to fit in 3 levels. There＇re 4% of PVP, 37.5% of microcrystalline cellulose, and 5% of CMS-Na. in the preferred prescription. The Azithromycin＇ s disintegration time is 57s, the accumulative dissolution of Azithromycin is 87% in 3 minutes. The preparation technology of Azithromycin dispersible tablets is feasible, the dissolution rate is swift.