103株金黄色葡萄球菌耐药性分析

Resistance to anti-microbial drugs of clinical staphylococcus aureus strains

目的了解临床金黄色葡萄球菌耐药性状,为治疗由金黄色葡萄球菌引起的疾病提供依据。方法收集各类临床标本进行金黄色葡萄球菌分离鉴定并进行药敏试验。结果分离出的103株金黄色葡萄球菌主要来源于分泌物、痰、尿等标本,以烧伤创面分泌物分离的金黄色葡萄球菌医院感染率最高。对青霉素、四环素、苯唑西林凝固酶阴性葡萄球菌耐药率高达94.17%、50.46%、37.86%,出现了30种耐药谱,对3种以上药物的多种耐药株达43.69%,最多耐药种类达7种。结论本研究结果表明,金黄色葡萄球菌对多数抗菌药物存在不同程度的耐药,成为临床治疗及院内感染的潜在危险,提示安全应用治疗药物的重要性。加强对临床分离株的耐药监测对治疗并参考耐药谱实施合理用药以防止多重耐药株出现有一定意义。

Objective To learn the status of resistance to anti-microbial drugs in clinic staphylococcus aureus strains. Methods Collected clinical samples such as secretion, sputum and urine etc. ,isolated from staphylococcus aureus strains and made antimicrobial resistance tests. Results 103 strains of S. aureus were detected mainly from secretion,sputum,urine and surface of wounds, S. aureus isolates were resistant to penicillin（94. 17%）, followed by tetracycline and oxacillin COAG（50.46 %and 37.86 % respectively） and occurred 30 resistance phenotypes, with the most to 7 kinds of drugs,and 43.69% of all tested strains were multi-anti.microbial resistance to 3 kind of drugs. Conclusion The data showed that S. aureus had highly resistance to different kinds of antimicrobials and became potential hazards to clinical treatment. The monitor of S. aureus drug-resistance could give guide to clinical treatment and provide epidemiologic and dynamic data changes for clinic.