尿路感染常见病原菌分析

Analysis of common pathogens of urinary tract infection

目的了解本院尿路感染常见病原菌的分布及耐药情况,为临床合理选用抗菌药物提供依据。方法对本院2008年1～12月住院及门诊患者尿培养阳性非重复分离的164株病原菌进行回顾性分析。结果尿路感染常见病原菌以革兰阴性杆菌为主,有125株(76.2%),其中尤以大肠埃希菌分离率最高,有104株(63.5%);革兰阳性球菌35株(21.4%);真菌4株(2.4%)。大肠埃希菌的产超广谱β-内酰胺酶(ESBLs)检出率为60.6%(63/104),产ESBLs株大肠埃希菌的耐药率明显高于非产ESBLs株;革兰阳性球菌耐药情况严重。结论尿路感染常见病原菌以革兰阴性杆菌为主,临床应重视病原学检查,根据药敏试验结果合理使用抗菌药物。

Objective To investigate the distribution and drug resistance for clinical antimicrobial agents of the common urinary tract infection in our hospital,so to provide a reasonable basis for selection. Methods 164 pathogens of culture positive urine separation of non-duplication isolated from the patients in our hospital from Jan. to Dec. of 2008 were retrospectively analyzed. Results Common pathogens of urinary tract infection are mainly caused by gram- negative bacilli（125,76.2% ）, particularly among the highest rates of Escherichia coli isolated（104,63.5 %）. There are 35 gram positive cocci,accounting for 21.4% ; 4 fungi,accounting for 2.4% ; the ESBLs in Escherichia coli detec- tion rate is 60. 6% （63/104）, and escherichia eoli strains producing ESBLs of the resistance is significantly higher than that of non-ESBLs producing strains; resistant gram-negative cocci is in serious condition. Conclusion Common pathogens of urinary tract infection is mainly caused by gram negative bacilli,and in clinical examination,more affen tion should loe paid to etiology,according to the results of the rational use of drug susceptibility of antimicrobial agents.