摘要
Six alkaloids,2-(1H-indol-3-yl)-4H-benzo[d]oxazin-4-one(1),methyl o-(indole-3-carboxamido) benzoate(2),cyclo(Ile-Leu-Val-Va1)(3),cyclo(Phe-Gly)(4),cyclo(Leu-Leu)(5),and cyclo(Ala-Leu)(6),were isolated from the mangrove endophytic fungus ZSU-H26 from the South China Sea.Their structures were elucidated by spectral data.Indole alkaloids 1 and 2 were both isolated from microorganism for the first time.In the preliminary bioassay,1 and 2 show inhibitory activity on the hepG2 cell line with IC50 values of 20μg/mL and 35μg/mL,respectively.
Six alkaloids,2-（1H-indol-3-yl）-4H-benzo[d]oxazin-4-one（1）,methyl o-（indole-3-carboxamido） benzoate（2）,cyclo（Ile-Leu-Val-Va1）（3）,cyclo（Phe-Gly）（4）,cyclo（Leu-Leu）（5）,and cyclo（Ala-Leu）（6）,were isolated from the mangrove endophytic fungus ZSU-H26 from the South China Sea.Their structures were elucidated by spectral data.Indole alkaloids 1 and 2 were both isolated from microorganism for the first time.In the preliminary bioassay,1 and 2 show inhibitory activity on the hepG2 cell line with IC50 values of 20μg/mL and 35μg/mL, respectively.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2009年第11期1566-1570,共5页
Chemical Research and Application
基金
国家863计划资助项目(2006AA09Z422)
国家自然科学基金资助项目(20072058和20572136)
广西自然科学基金资助项目(0832081)
广西民族大学科学研究基金资助项目(200702YJ18)
