Castleman病转化为霍奇金淋巴瘤一例并文献复习

A case report Of Castleman＇s disease transformed into Hodgkin＇s lymphoma with literature review

目的 分析Castleman病的病因及发病机制、临床及病理特点、诊断、治疗及预后。方法 对1例Castleman病转化为霍奇金淋巴瘤的病例进行分析并进行文献综述。结果 Castleman病是一种以滤泡增生和毛细血管增生为组织学特征的淋巴结良性增生性疾病。根据病理学特点分为透明血管（HV）型、浆细胞（PV）型及兼有两者特点的混合细胞型。其临床表现复杂多变，除淋巴结肿大外尚可有全身表现及多系统受累症状，早期确诊主要靠组织病理学诊断，病理类型不同预后也不同，局灶型（LCD）患者预后良好，可能长期带病生存，多中心型（MCD）具有侵袭性，预后差。结论 Castleman病不同的病理类型其临床表现及预后也不同。

Objective To understand the cause and pathogenesis,clinical and pathological features,diagnosis,treatment and prognosis of Castleman＇s disease （CD）. Methods One patient with CD which has transformed into Hodgkin＇s lymphoma in the end was analyzed and the review were included. Results Castleman＇s disease was a lymphoproliferative disorder with benign hyperplastic lymphnodes histologically characterized by follicular hyperplasia and capillary proliferation with endothelial hyperplasia. Based on the characteristic of pathology it was subdivided into three subtypes, hyaline vascular variant, plasma cell variant and mixed variant. The clinical manifestation of CD was multiplicity,including the lymphadenectasis and the involvement of the multisystem of the body. The early diagnosis was depended on the histopathology,and the different histopathology has the distinct prognosis. The prognosis of local Castleman＇s disease （LCD） was good but the multicentric Castleman＇s disease （MCD） was poor. Conclusion The different histopathology of CD were determined according to the different clinical manifestations and prognosis.