原发性中枢神经系统淋巴瘤预后相关因素研究进展

Advances in relevant prognostic factors of primary central nervous system lymphoma

原发性中枢神经系统淋巴瘤（PCNSL）是一种少见的结外恶性淋巴瘤，好发于免疫缺陷人群，但近年来在免疫功能正常人群中发病率逐年提高。其临床治疗缓解期短，易复发，预后不佳。研究发现PCNSL的预后相关因素包括：年龄、体力状态、放化疗的方式、初治对糖皮质激素的反应、组织病理和分子生物学标志等。

Primary central nervous system lymphoma （PCNSL） is a rare type of malignant lymphoma which originates in the central nervous system without spreading to other systems. It is more predisposable to immunodeficient individuals. However, an increase in the incidence of PCNSL has been also observed in the healthy population in recent years. PCNSL has short phase of clincal release, and easy to relapse with poor prognosis. Some studies have shown that relative prognostic factors were associated with age, performance status, the radiotherapy and chemotherapy modalities, the response to early adminstration of the glucocorticoid, tissue pathologic type and the molecular biologic marks.