Survivin与 白血病

Survivin and leukemia

Survivin是IAP家族中最年轻的成员，在几乎所有的肿瘤细胞中高表达，而在大多数的正常细胞中没有检测到。由于其表达的选择性引起人们的兴趣，认为是肿瘤细胞的分子标志之一。同样Survivin已经在多数的白血病细胞株和白血病标本中被检测到，并展示了其表达与白血病的关系。同其他肿瘤细胞一样，Survivin在白血病的发病中起到重要作用，同时Survivin的检测可以提供有用的预后信息。现就Survivin的研究进展以及与白血病的关系做简要综述。

Survivin is the most recent member of the IAP family, which shows a higher expression in almost all tumor cells, but not detected in most normal cells. Our attention is drawn by survivin due to its selective expression, which was taken as one molecule sign of tumor cells. Accordingly, survivin is examined in most leukemia cell line and leukemia specimen, whose expression also showed the association with leukemia. As in other tumor cells, survivin also plays an important role in the leukemogenesis. Meanwhile the detection of survivin can provide an useful prognosis information. This article is a brief overview of the development of survivin and its relationship with leukemia.