HLA-DR等位基因与中国人群肺结核关联性的Meta分析

Meta-Analysis of the Association of HLA-DR Genetic Polymorphism with Pulmonary Tuberculosis in Chinese Population

目的应用Meta分析方法探讨中国人群HLA-DR基因多态性与肺结核易感性的关系。方法通过全面检索查找已发表的有关中国人群肺结核与HLA-DR基因关联性的文献。以肺结核组和健康对照组的HLA-DR等位基因型频数分布的比值比为统计量,采用RevMan5.0.13进行Meta分析。结果符合纳入标准的文献共7篇。Meta分析及敏感性分析发现,病例组和对照组DR4、DR16、DRB1*15和DRB1*13.2的合并比值比及其95%可信区间分别为1.64(1.08,2.50)、2.08(1.32,3.28)、2.94(1.34,6.49)和0.32(0.14,0.72)。结论 DR4和DR16可能是南方汉族人群的易感基因;DRB1*15可能是北方汉族人群肺结核的易感基因,DRB1*13.2可能是其保护基因。

Objective To evaluate the association between gene of HLA-DR and pulmonary tuberculosis in Chinese population by meta-analysis method. Methods Electronic searches were conducted roundly to find literatures about the relationship between pulmonary tuberculosis in Chinese population and HLA-DR. We analyzed odds ratios （OR） of HLA-DR genotype distributions in pulmonary tuberculosis patients against healthy controls by RevMan 5.0.13. Results 7 studies that met the eligibility criteria were involved. The results of recta-analysis and sensitivity analysis were the pooled OR （95% CI） of DR4, DR16, DRBI＊15 and DRBI＊13.2 in case and control group were 1.64（1.08, 2.50）, 2.08（1.32,3.28）, 2.94（1.34,6.49） and 0.32（0.14,0.72） respectively. Conclusions For Chinese southward population, DR4 and DR16 can be regarded as susceptive gene of pulmonary tuberculosis. For Chinese northward population, DRB1 ＊ 15 can be regarded as susceptible gene of pulmonary tuberculosis and DRB1 ＊ 13.2 may be protective gene.