环境内分泌干扰物与青春发动时相提前

Environmental Endocrine Disruptors and Advanced Puberty Timing

自19世纪末至20世纪中期以来,越来越多的研究表明,人类的青春期性征发育或性功能发育年龄正在提前,其中原因可能既有个体遗传背景,也有环境因素,如宫内发育受限、卫生及营养状况改善、经济水平提高等。有关上述原因与青春发动时相提前的一个重要理论假设就是环境内分泌干扰物的暴露导致青春发动时相提前。现就环境内分泌干扰物对青春发动时相的影响作一简要综述。

More studies indicate that puberty start at a younger age from the late 1800s to the mid - 1900s,these changes are apparently caused by genetic predisposition and environmental factors such as fetal growth restriction,improved health care and nutrition,improved socio - economic status. One prominent hypothesis is that exposure to environmental endocrine disruptors（EEDs） cause an earlier age of puberty. In this overview of the literature, the effect of environmental endocrine disruptors on the onset of puberty is summarized.