参芪扶正注射液对老年慢性心力衰竭患者心功能的影响

Effect of Shenqifuzheng Injection on Cardiac Function in Aged Patients with Chronic Heart Failure

目的观察参芪扶正注射液对老年慢性心力衰竭患者的临床疗效及对其心功能、脑钠肽(BNP)的影响。方法将64例65岁以上的慢性心力衰竭患者随机分为治疗组(n=34)和对照组(n=30)。对照组常规使用吸氧、强心、利尿、扩张血管、纠正水电解质紊乱等治疗,治疗组则在对照组的基础上加用参芪扶正注射液(250ml/d),疗程3周。观察治疗前后患者的NYHA心功能分级、左心室舒末内径(LVEDD)、左室射血分数(LVEF)、心排血量(CO)与血浆脑钠肽(BNP)含量。结果治疗后两组患者的心功能各项指标与BNP均得到显著改善(P<0.05)。其中治疗组的NYHA心功能分级改善有效率明显高于对照组(P<0.05),治疗后治疗组的LVEF、CO与血浆BNP含量与对照组有显著差异(P值均<0.05),两组治疗后的LVEDD则无明显差异(P>0.05)。结论参芪扶正注射液联合常规治疗可以提高对老年慢性心力衰竭患者的疗效,改善心功能。

Objective To investigate the effect of Shenqifuzheng injection on the therapeutic effect and cardiac function and brain natriuretic peptide（BNP） in aged patient with chronic heart failure.Methods 64 patients age more than 65 years with chronic heart failure were randomly divided into two groups：the treatment group（n=34） and control group（n=30）.Patients in the control group were given routine treatment with correcting the fluid and electrolyte imbalance,and the patients in the treatment group were given additional Shenmai injection 100 ml every day. The course of treatment was 3 weeks. The NYHA class index, left ventricular end diastolic diameters （LVEDD）, left ventricular ejection fraction（LVEF）, cardiac output（CO） and serum BNP of the patients were measured before and after treatment. Results Every index of cardiac function and BNP of patients in two groups were significantly improved （P〈0.05）. The total effective ratios of the improvement on NYHA class in patients in treatment group is significantly higher than those in control group （P〈0.05）. And the LVEF, CO and serum BNP of patients in treatment group after therapy were significantly different to the patients in control group （P〈0.05）, but there were no difference of the LVEDD of patients between two groups （P〉0.05）. Conclusion Shenqifuzheng injection association with routine treatment can improve the therapeutic effect and cardiac function of the aged patients with chronic heart failure.