用Roc曲线评价血清a-L-岩藻糖苷酶在原发性肝癌中的诊断价值

Evaluating the Diagnostic Value of Serum Alpha-L-fucosidase in Primary Hepatic Carcinoma by Receiver Operating Characteristic Curves

目的运用Roc曲线通过与AFP比较评价a-L-岩藻糖苷酶(AFU)在原发性肝癌中的诊断价值,确定本实验室条件下的血清AFU用于诊断原发性肝癌的临界值,并比较AFU和AFP的筛查价值,为原发性肝癌的实验室诊断提供依据。方法对89例原发性肝癌,120例其他肝病及202名健康体检者,联合检测AFP和AFU,利用SPSS11.5统计软件绘制ROC曲线,通过比较这两种诊断试验的ROC曲线下面积来比较其诊断价值。结果ROC曲线下面积AFU为0.869,AFP为0.896,两者间差异有统计学意义。结论AFP的筛查价值略高于AFU,根据ROC曲线确定本实验室AFU临界值为32U/L。

Objective The purpose of this study is to evaluate the diagnostic value of alpha-L-fucosidasen in primary hepatic carcinoma and determine the cut-off value of AFU by Receiver Operating Characteristic（ROC） curves,and comparing the diagnostic value with alpha-fetoprotein.Methods Serum AFU and AFP were measured in 89 patients with PHC,120 with other liver diseases and 202 controls.ROC curves were analyzed by SPSS11.5 and then compared the areas under ROC curves.Result Areas under ROC curves of AFU is 0.869 and AFP is 0.896.Conclusion AFP is superior to AFU in the diagnosis of PHC. The cut-off value of AFU in the diagnosis of PHC is determined as 32 U/L.