炎琥宁治疗小儿手足口病的临床疗效

Clinical Effect of Yanhuning in the Treatment of Infantile Hand-Foot-Mouth Disease

目的观察炎琥宁治疗小儿手足口病的临床疗效。方法将141例手足口病患儿随机分为治疗组(72例)和对照组(69例)。对照组给予以利巴韦林10～15mg/kg·d,每日1次静脉输入,疗程7d;治疗组给予炎琥宁10mg/kg·d,每日1次静脉输入,疗程7d,并对临床有效率及有效时间进行比较分析。结果治疗组72例,治愈42例,好转20例,总有效率为91.6%;对照组69例,治愈32例,好转9例,总有效率为59.4%,两组总有效率比较差异有统计学意义(P<0.01)。两组发热、皮疹及口腔疱疹消退时间比较,治疗组热退时间为(2.23±1.22)d,皮疹消退时间为(3.31±1.35)d;对照组热退时间为(4.98±1.82)d,皮疹消退时间为(5.84±1.93)d,经统计学处理热退时间、皮疹消退时间比较差异有统计学意义(P<0.01)。结论本组炎琥宁治疗小儿手足口病疗程短、见效快、未见不良反应发生。但应用时需注意炎琥宁注射液本身所存在的不良反应,如过敏、发热、血细胞减少、胃肠道反应、神经精神症状等,一般疗程应<1周,每1ml溶媒中使用炎琥宁≤1mg,连续使用>1周的患者,应注意密切观察加强监测,避免超剂量及高浓度静脉滴注给药。

Objective To evaluate the clinical effects of Yanhuning in the treatment of infantile hand-foot-mouth disease.Methods 141 children with infantile hand-foot-mouth disease were randomly divided into two groups：72 cases for the treatment group and 69 cases for the control group.In the control group,ribavirin（10～15 mg /kg /d） was intravenously administered once per day for 7 days.In the treatment group,Yanhuning（10 mg /kg /d） was intranvenously injected once per day for 7 days.Clinical efficacy and the effective time were compared and analyzed. Results In the control group, 32 cases were cured and 9 cases were recovered. The total effective rate was 59.4%. In the treatment group, 42 cases were cured and 20 cases were recovered. The total effective rate was 91.6% and the result was significantly different from the control group （P〈0.01）. The recovery time of fever, rash and oral herpes were also compared between the two groups. In the control group,the recovery time of fever and rash wei＇e （4.98＋1.82） days and （5.84＋1.93） days, respectively. In the treatment group,the recovery time of fever and rash were （2.23~1.22） days and （3.31~1.35） days,respectively,and the difference was significant （P〈0.01）. Conehtsion Yanhuning is an effective drug in the treatment of infantile hand-foot-mouth disease.Yanhuning was found to have no toxic side effects, with a short course of treatment and the effect was rapid.The side effects included allergy, fever, reduction of baemoeytes, gastrointestinal reactions, and neurotic mental reaction. Course of treatment （1 mg/mL） is generally within a week. Close supervision and monitoring should be performed when it was used for more than 1 week. Intravenous injection with a high concentration of Yanhuning should be avoided.