精氨酸酶在结直肠癌原发灶及转移灶组织中的表达及意义

Arginase expression and its relationship with genesis and metastasis of human colorectal cancer

目的研究精氨酸酶在结直肠癌原发灶及转移灶组织中的表达及其意义,探究其在结直肠癌转移中的作用及临床应用价值。方法应用免疫组化方法检测正常肠粘膜、结直肠癌原发灶、淋巴结转移灶及肝转移灶中人精氨酸酶的表达,并进行数据统计分析。结果在不同分期的结直肠癌不同组织中,人精氨酸酶的表达有规律性的变化。癌组织中人精氨酸酶的表达显著高于正常肠粘膜组织(P<0.01),转移癌组织中人精氨酸酶阳性表达率比Ⅱ期癌原发灶组织明显增高(P<0.05);肝转移灶组织与淋巴结转移灶组织中人精氨酸酶的表达率无明显差异(P>0.05)。结论人精氨酸酶在Ⅲ期、Ⅳ期结直肠癌原发灶组织及各种转移组织中高表达,可能与结直肠癌的转移相关。

Objective To evaluate the arginase expression and its relationship with genesis and metastasis of human colorectal cancer. Methods The expression of arginase was detected by immunohistochemical method in normal colorectal mucosa, primary cancer lesion and metastases of different staging colorectal cancer. The data was statistically analyzed. Results There is regularity change in different tissue of different Staging colorectal cancer. Higher levels of arginase expression were showed in colorectal cancer tissue than in normal colorectal mucosa（ P 〈0.01 ）. The arginase expression in metastases tissue was significant than in primary cancer lesion with staging Ⅱ colorectal cancer（P 〈 0.05 ） , The arginase expression tended to be about same between liver metastases with lymph node metastases（ P 〉 0.05 ）. Conclusions Higher levers of arginase expression were showed in the primary cancer lesion and metastasis of staging Ⅲ and Ⅳ colorectal cancer, Higher levers of arginase expression may be correlation to metastases of colorectal cancer.