光动力疗法治疗上消化道肿瘤的护理配合与疗效观察

Nursing and Effect of Photodynamic Therapy on Upper Gastrointestinal Tumor

目的探讨光动力疗法治疗上消化道肿瘤的护理与疗效。方法食管癌、胃癌和十二指肠癌患者21例行静脉注射癌光啉5mg/kg,4～48h通过内镜孔插入光纤,以波长630nm的半导体激光照射病灶,功率密度100～150mW/cm2、能量密度180～270J/cm2、时间30min的半导体激光照射病灶。同时密切注意患者心理治疗及个体化的术前、术中、术后护理。结果术后1个月复查,完全显效4例(19.0%),明显显效5例(23.8%),部分显效12例(57.1%)无并发症发生。结论术中的护理配合及术后的病情观察是治疗的重要组成部分。

Objective To explore the role of nursing and the outcome of the photodynamic therapy （PDT） for upper GI lesions. Methods Twenty-one patients with esophageal on gastric duodenal cancers were included. Photocarcinorin of 5 mg/kg was injected iv for all patients 4-48 h before the PDT started. Laser with wave length of 630 nm, power density of 100-150 mW/cm^2 and energy density of 180-270 J/cm^2 was directed to the lesions via the instrumental channel of the gastroscopy for 30 rain. Psychological treatment and individualized nursing before, during and after therapy were provided for all patients. Results The complete remission rate was 19% （4 cases）, the obvious remission rate was 23.8% （5 cases） and the partial remission rate was 57. 1% （12 cases） during 1 month follow-up. Conclusions Intraoperative nursing care and postoperative observation are an important part in PDT.