Ames实验对丝素蛋白人工神经导管遗传毒性的研究

Evaluation of the genetoxic of silk fibroin-based nerve guidance conduit using Ames test

目的:初步评价自制的丝素蛋白人工神经导管的遗传毒性。方法:采用Ames试验常规方法进行检测。结果:丝素蛋白导管对TA97、TA98、TA100、TA102在加与不加S9条件下均无致突变性。结论:在本试验条件下丝素蛋白人工神经导管无直接或间接致突变性。

Objective：To study the effect of silk fibroin-based nerve guidance conduit （SF-NGC） which was prepared in our lab on mutagenicity. Methods：The studies were conducted with Ames test. Results：In Ames test, silk fibroin-based nerve guidance conduit had no mutagenicity on TA97, TA98, TA100 and TA102 with or without S9. Conclusion：No mutagenicity was observed with silk fibroin-based nerve guidance conduit in this study.