摘要
目的:研究Livin蛋白和Smac蛋白在肠癌组织及癌旁组织中表达的意义。方法:采用免疫组织化学Envision二步法检测60例肠癌组织及癌旁组织Livin和Smac蛋白的表达情况。结果:Livin蛋白在大肠癌组织中的阳性表达率80%,较癌旁组织3.3%高。Livin蛋白在癌组织过度表达与肠癌的淋巴结转移以及临床分期、组织分化程度有关。Smac蛋白在肠癌中的阳性表达率(30.0%)明显低于癌旁(96.7%),Smac表达降低或缺失与淋巴结转移及临床分期有关。经相关分析Livin和Smac蛋白的表达呈负相关。结论:Livin与smac蛋白在大肠癌的发生、发展中的作用有关。
Objective：To investigate the expression and significances of Livin and Smac in colorectal carcinomar and adjacent tissue. Methods： The expression of Livin and Smac proteins were detected by immunohistochemistry in 60 samples of colorectal carcinoma,and its adjacent tissue. Results： The positive rate of livin in cancerous tissue （80%） was higher than that in the adjacent tissue （3.3%）. The over expression of livin was correlated to the cancer invasive depth, lymph node metastasis and the clinical stage; the lower expression of Smac was correlated to the cancer differentiation, lymph node metastasis and the clinical stage. Concluslon：There was a negative relationship between livin and smac which were related to the development and progression of colorectal carcinoma.
出处
《交通医学》
2009年第5期476-477,481,共3页
Medical Journal of Communications
