摘要
目的:探讨CD133在食管鳞癌组织中的表达及其临床意义。方法:采用免疫组织化学方法检测肿瘤组织中CD133的表达情况,分析CD133的表达与食管鳞癌临床病理特征及预后的关系。结果:肿瘤组织中CD133的表达与肿瘤浸润深度、TNM分期、淋巴结转移及5年生存率相关(P<0.05),与组织分化无关(P>0.05)。结论:CD133的表达在食管鳞癌的发生、发展、转移中发挥重要作用,可考虑作为临床评价食管鳞癌肿瘤生物学行为及评估预后的指标之一。
Objectlve：To investigate the expressions of CD133 in human esophageal carcinoma （EC） and analyse their clinical significance. Methods ：The expression of CD133 was detected in 90 EC specimens with immunohistochemical staining. Resuhs：CD133 was correlated to infiltrative depth,clinical stage,and lymphatic invasion （P〈0.05）.The 5-year survival rate of the patients with CD133 expression was lower than that of the patients with negative expression （P〈0.05）.There was no evidence indicating which was relative with differentiation degrees（P〈0.05）. Conclusion：CD133 could play significant roles in the generation and evolution of esophageal carcinoma and might be used as useful indicators for clinical assessment of tumor biological behavior and prognosis in patients with esophageal carcinoma.
出处
《交通医学》
2009年第5期491-492,496,共3页
Medical Journal of Communications
