摘要
采用黄体生成素释放激素-A(LHRH-A)治疗前列腺癌睾丸切除术后复发或转移的患者5例(其中2例用过氟硝丁酰胺,1例用过磷酸雌二醇氮芥控制一段时期后复发),结果5例皆有效,其中4例已控制2年以上。提示LHRH-A不仅仅具有药物去势作用;若长期使用可起到选择性药物切除垂体,达到全雄性激素阻断的作用;对曾用过其他内分泌或化学药物治疗无效的患者,LHRH-A仍然有效。建议对LHRH-A治疗人类前列腺癌的作用机制作进一步的研究。
5 cases of the recurrence and metastasis of prostatic carcinoma following orchiectomy has been treated with luteinizing hormone releasing hormone agonist (LHRH-A) since 1994.The results showed that it was effective in all patients and theses diseases were controlled for more than 2 years in 4 cases. It was suggested that LHRH-A not only had the effect of drug orchiectomy, but also had select drug pituitectomy and blocking all androgen. It was considered that the mechanism of LHRH-A for the treatment of prostatic carcinoma should be studied further.
出处
《临床泌尿外科杂志》
1998年第12期519-521,共3页
Journal of Clinical Urology
关键词
前列腺肿瘤
睾丸切除术
激素治疗
LHRH-A
Prostatic carcinoma
Orchiectomy
Luteinizing hormone releasing hormone agonist