黄体生成素释放激素-A治疗前列腺癌睾丸切除后复发转移疗效的探讨(附5例报告)

Luteinizing hormone releasing hormone agonist for the treatment of the recurrence and metastasis of prostatic carcinoma following orchiectomy

采用黄体生成素释放激素-A（LHRH－A）治疗前列腺癌睾丸切除术后复发或转移的患者5例（其中2例用过氟硝丁酰胺，1例用过磷酸雌二醇氮芥控制一段时期后复发），结果5例皆有效，其中4例已控制2年以上。提示LHRH－A不仅仅具有药物去势作用；若长期使用可起到选择性药物切除垂体，达到全雄性激素阻断的作用；对曾用过其他内分泌或化学药物治疗无效的患者，LHRH－A仍然有效。建议对LHRH－A治疗人类前列腺癌的作用机制作进一步的研究。

5 cases of the recurrence and metastasis of prostatic carcinoma following orchiectomy has been treated with luteinizing hormone releasing hormone agonist (LHRH-A) since 1994.The results showed that it was effective in all patients and theses diseases were controlled for more than 2 years in 4 cases. It was suggested that LHRH-A not only had the effect of drug orchiectomy, but also had select drug pituitectomy and blocking all androgen. It was considered that the mechanism of LHRH-A for the treatment of prostatic carcinoma should be studied further.