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Zn/I_2促进的S—S键断裂用于合成α-硫代酯和α-硫代腈

Synthesis of α-thio esters and nitriles via cleavage of S—S bonds promoted by Zn/I_2 in DMF
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摘要 二硫醚在二甲基甲酰胺(DMF)中被Zn/I2还原,发生S—S键的断裂,生成硫负离子,随后与α-溴乙酸乙酯或α-溴乙腈反应,分别生成α-硫代酯和α-硫代腈,产率为79%-91%. Thio anions,which were produced by reductive cleavage of disulfides by Zn/I2 in DMF,underwent nucleophilic substitution with α-bromo ethyl acetate and α-bromo acetonitrie smoothly,α-thio esters and α-thio nitriles were obtained with good yields rate of 79%~91%.
出处 《浙江师范大学学报(自然科学版)》 CAS 2009年第4期437-441,共5页 Journal of Zhejiang Normal University:Natural Sciences
关键词 Zn/I2 二硫醚 α-硫代酯 α-硫代腈 亲核取代 Zn/I2 disulfides α-thio esters α-thio nitriles nucleophilic substitution
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