64排螺旋CT联合基质金属蛋白酶检测对判定冠状动脉斑块稳定性的诊断价值

The diagnostic value of 64-slice computed tomography combine with matrix metalloproteinases examination in the diagnosis of stability of the coronary atherosclerotic plaques

【目的】探索64排螺旋CT联合基质金属蛋白酶检测对冠状动脉斑块稳定性的诊断价值及应用性。【方法】选取临床确诊冠心病患者97例,随机分为稳定型心绞痛组(SAP)和急性冠脉综合征组(ACS)。分别进行64排螺旋CT冠状动脉扫描检查和血清MMP-2、MMP-9、TIMP-1、TIMP-2测定。并对所得结果进行独立样本t检验和单因素方差分析。【结果】在ACS组软斑块、混合斑块的分布显著高于硬斑块,而在SAP组硬斑块的分布显著高于ACS组(P<0.01)。易损斑块组(软斑块、混合斑块)组血清MMP-2、9,MMP-2/TIMP-2,MMP-9/TIMP-1水平显著高于稳定斑块及无斑块组(P<0.01),易损斑块及稳定斑块组间TIMP-1、2水平无显著统计学差异。【结论】64排螺旋CT冠脉斑块检查结合血清MMPs、TIMPs水平检测可作为冠状动脉斑块不稳定性的预测指标。

【Objective】To explore the value of 64-slice computed tomography combine with matrix metalloproteinases examination in the diagnosis of stability of the coronary atherosclerotic plaques.【Methods】There are 97 patients with coronary heart disease,and were randomly divided into stable anginapectoris（SAP） group and acute caronary syndrome（ACS） group.Serum MMP-2、MMP-9,TIMP-1 and TIMP-2 level,were determined and major and minor branches of coronary arteries were examined by 64-slice CT.【Results】Distribution of soft plaque and mixed plaque was higher than hard plaque in ACS group,and there were more hard plaque in SAP group than in ACS group.The level of serum MMP-2,9,MMP-2/TIMP-2 and MMP-9/TIMP-1 in soft plaque and mixed plaque was significent higher than hard plaque.【Conclusions】64-slice computed tomography combine with matrix metalloproteinases examination canbe used to diagnose the stability of the coronary atherosclerotic plaques.