水蛭素缓释、控释给药系统的研究进展

Progress in the Controlled Release Systems of Hirudin

水蛭素是新型高效抗凝抗血栓药物，正被开发成不同缓释、控释系统，用于人体血栓的预防和治疗。本文将对几种常见的控释系统进行概述，特别对水蛭素一生物可降解聚合的支架（ｓｔｅｎｔ）的特点，功效以及对冠脉病变部位的定位释放进行介绍，这种控释系统对ＰＴＣＡ术后的再栓塞具有很好的疗效。

Hirudin is very effective in treating and preventing cardiovascular disorders. In this review several polymeric controlled release systerms of hirudin are introduced. The advantages of the local delivery for restenosis and the feasibility of endovascular drug containing pharmaceutic stents for local therapy of cardiovascular thrombosis are discussed.