用原子力显微技术测定生物分子之间的相互作用力

Measurement of Forces Between Biomolecules by Atomic Force Microscopy

原子力显微技术（ＡＦＭ）可直接测定生物大分子之间的作用力，为人们理解生命原理提供了一个新的手段。目前已用ＡＦＭ对一些在生命科学中具有重要意义的生物大分子之间的作用力进行了测定如：①配体受体之间的相互作用力；②运动蛋白之间的作用力；③细胞粘附糖蛋白之间的作用力；④核酸双链和碱基对氢键之间的相互作用力；⑤特殊化基团之间的作用力。本文综述其有关文献。

The intermolecular forces of the biological samples may be measured by atomic force microscopy, which has provided a powerful means for us to understand the principles of living phenomena. Some systems in which the interaction forces between biomolecules have been measured hitherto include:①ligand receptor;②actin myosin;③proteoglycans;④DNA complementary strands and nucleotides;⑤special organic chemical groups. A literature review on these objects is presented in this article.