内皮素及细胞因子在冠心病发病中的意义

Effect on endothelin and cytokines on the pathogenesis of coronary heart disease

检测３５例冠心病患者及２０例健康者血浆内皮素（ＥＴ）、血清肿瘤坏死因子（ＴＮＦ）及白细胞介素－６（ＩＬ－６）的水平。结果显示：与正常组比较，冠心病组ＥＴ及ＴＮＦ水平均增高（Ｐ＜０．０１），尤以心肌梗死组为明显（Ｐ＜０．０１）；冠状动脉狭窄组与对照组比较，ＩＬ－６水平无明显变化（Ｐ＞０．０５），但心肌梗死组ＩＬ－６水平则明显增高（Ｐ＜０．０１）。提示血浆ＥＴ浓度及细胞因子的作用与冠心病的发生发展有关；

The plasma levels of endothelin(ET), serum levels of tumor necrosis factor(TNF) and interleukin 6(IL 6) in 35 patients with coronary heart disease(CHD) and 20 healthy people were studied by radioimmunoassay and enzymebinded immunosorbent assay(ELISA). The results showed that the plasma ET level and the serum TNF level in the CHD group, especially the acute myocardial infarction(AMI) group, were much higher than those of the control group (P<0.01). There was no obvious statistical difference on IL 6 levels between the narrowed coronary artery group and the control group (P>0.05). But the serum level of IL 6 in the AMI group was significantly higher than that of the other groups (P<0.01). These findings indicate that ET and cytokine levels may play an important role on the pathogenesis of coronary heart disease.