稀化黏素胶囊和布地奈德鼻喷雾剂治疗分泌性中耳炎临床疗效分析

Observation on therapeutic effect of standardized myrtol and budesonide on secretary otitis media

目的观察稀化黏素和布地奈德治疗分泌性中耳炎(SOM)的疗效。方法232例(280耳)分泌性中耳炎病人中治疗组124例(150耳),在常规用药的基础上加服稀化黏素,并使用布地奈德喷鼻;对照组108例(130耳),予常规用药治疗。2、3周后随访,观察两组治疗前后症状、体征、纯音测听和鼓室压图的变化。结果治疗组主观症状、耳部检查、纯音测听、声阻抗检查等各项观察指标总有效率分别为94.0%、94.7%、93.3%和94.0%,与对照组各项观察指标总有效率64.6%、73.9%、63.8%和64.6%比较,治疗组均优于对照组,差异均有显著性(P<0.05)。结论口服稀化黏素并鼻腔喷用布地奈德能有效提高分泌性中耳炎的临床疗效。

Objective To observe the therapeutic effect of standardized myrtol and budesonide on secretary otitis media（SOM）.Methods Two hundred and thirty two patients（280 ears）with SOM were randomly divided into two groups,124 cases（150 ears）in treatment group were treated with routine medication combined with oral administration of standardized myrtol and nasally spraying budesonide,and 108 cases（130 ears）in control group were only treated with routine medication.Changes in symptoms,signs,graphes of tympanil pressure and pure-tone audiometry were observed among patients of these two groups in 2～3 weeks after treatment.Results Subjective symptoms,ear examination,pure tone audiometry,acoustic impedance etc were observed as indicators for check,and their total effective rates in patients of treatment group were 94.0%,94.7%,93.3% and 94.0% respectively,and they were better than those of 64.6%,73.9%,63.8% and 64.6% respectively in patients of control group.Their differences were statistically significant（P0.05）.Conclusion Oral administration of standardized myrtol combined with nasally spraying budesonide can improve the therapeutic effect of patients with SOM.