碳酸钙泡腾颗粒的人体生物利用度研究

The bioavailability of calcium carbonate effervescent granules in healthy volunteers

目的：评价碳酸钙泡腾颗粒的人体生物利用度。方法：以原子吸收光谱法测定１０名健康志愿者口服碳酸钙泡腾颗粒与进口碳酸钙片后的尿钙浓度，以尿钙总排泄量与尿钙增量为指标评价两种制剂吸收差异。结果：口服１．２ｇ碳酸钙泡腾颗粒与碳酸钙片后４ｈ尿钙总排泄量分别为０．１４３ｍｇ·（ｍｇＣｒ）－１与０．１０９ｍｇ·（ｍｇＣｒ）－１；尿钙增量分别为０．０５１ｍｇ·（ｍｇＣｒ）－１与０．０３１ｍｇ·（ｍｇＣｒ）－１，前者均显著高于后者（Ｐ＜０．０５和Ｐ＜０．０１）。结论：碳酸钙泡腾颗粒的口服生物利用度高于碳酸钙片。

Objective:To investigate the bioavailability of calcium carbonate effervescent granules in healthy volunteers.Methods:The urinary calcium were determined by atomic absorption spectrophotometry after a single oral dose of calcium carbonate effervescent granules and calcium carbonate tablet was given to 10 healthy volunteers.Results:The urinary calcium following calcium carbonate effervescent granules was significantly higher whether expressed as the total amount or as the increment above basal (fasting) excretion.Conclusion:The bioavailability of calcium carbonate effervescent granules was higher than calcium carbonate tablet.