泌尿男生殖系统疾病对血清PSA水平的影响

Serum prostatic specific antigen in urologic and male genital diseases

前列腺特异抗原(PSA)作为前列腺癌的肿瘤标志物越来越受到重视,为了探讨泌尿男生殖系统疾病对血清 PSA 水平的影响,我们采用 ELISA 方法定量检测127例泌尿男生殖系统患者和40例年龄在40岁以下的健康者血清 PSA,发现前列腺癌血清 PSA 浓度明显升高(P<0.01),前列腺增生和前列腺炎患者的血清 PSA 浓度也有所增加(P<0.05),泌尿道感染及健康组均无升高,结果显示血清 PSA 浓度作为前列腺癌的肿瘤标志物有较高的特异性。

Prostatic Specific Antigen(PSA)has received more and more attention as a tumor marker of prostatic cancer.In order to find out the influence of diseases of male urogenital system on the serum PSA level,the serum PSA of 127 patients of male urogenital system and 40 healthy people whose ages were under 40 was tested quantitatively with ELISA.It was found that the serum PSA concentration in prostatic cancer patients rose evidently(P<0.01),while that of others had not any rise except slight rise(P<0.05)happened to that of prostate hypertrophy and prostatic inflammation patients.So,it has high specificity to use serum PSA determination as the tumor marker of prostatic cancer.