11例胃肝样腺癌患者的病理与临床特征分析

Pathological character and clinical analysis of the hepatoid adenocarcinoma of stomach:A report of 11 cases

目的:探讨胃肝样腺癌(hepatoid adenocarcinoma of stomach,HAS)特殊的临床病理特点和预后的关系,以指导临床治疗。方法:回顾性分析我院11例曾行外科手术切除,术后经病理证实为胃肝样腺癌的患者的多个临床及病理参数。结果:11例患者中男性7例,女性4例,平均年龄61.5岁,5例术前已有肝转移,4例术后发生肝转移。发病部位以胃窦部小弯侧多见(54.5%),病理类型多为溃疡型(72.7%)。结论:胃肝样腺癌是原发于胃黏膜腺体的肿瘤,形态上具有肝细胞样分化和腺癌样分化两种结构,因常伴有淋巴转移及肝转移,故预后较普通型胃癌差。

Objective：To investigate the relation between the special clinical and pathological features and prognosis of the hepatoid adenocarcinoma of stomach（HAS）,and to guide clinical treatment.Methods：Retrospective analysis of the pathological and clinical characteristics were studied in 11 cases,who had been operated and final diagnosed as HAS through pathologic diagnosis.Results：In the 11 cases,male 7,female 4,the mean age was 61.5 years old,and there were 5 cases with liver metastasis before the operation,4 cases with liver metastasis after the operation.Most invasion was in sinus ventriculi（54.5%）,and the pathologic type was mostly anabrosis（72.7%）.Conclusion：HAS is a gastric carcinoma with both hepatocellular and adenomatoid differentiation.Its prognosis is often poor because of frequant hepatic metastasis and lymphatic metastasis.