平行板流动小室在肿瘤研究中的应用

Application of parallel-plate flow chamber in cancer research

平行板流动小室是细胞力学体外实验中最常用的装置之一,越来越多的研究利用平行板流动小室提供剪应力,模拟肿瘤细胞生长的体内环境,探讨肿瘤细胞增殖、黏附和扩散的机制;亦有研究在平行板流动小室的基础上建立了肿瘤检测装置,开辟了生物力学与肿瘤学有机结合的新领域。本文综述了平行板流动小室在肿瘤研究中的应用现状。

Parallel-plate flow chamber is a widely used equipment in studying cellular mechanics in vitro. Many researchers used parallel-plate flow chamber to provide shear stress and to mimic in vivo the environment of cancer cell growth. It is a versatile tool in understanding the mechnisms of proliferation, adhesion, and metastasis of cancer cell. Cancer-detecting devices were also developed based on parallel-plate flow chamber. A new field overlapping biomechanics and cancer research was developed. Application of parallel-plate flow chamber in cancer research is reviewed in this paper.