吸入一氧化氮对犬烟雾吸入性损伤心肌酶谱的影响

Effect of inhaled nitric oxide on myocardial enzyme spectrum after smoke inhalation injury in dogs

目的：本研究旨在评价吸入一氧化氮（ＮＯ）在犬烟雾吸入性损伤时对心肌酶谱的影响。方法：烟雾吸入后，用１７只犬随机分为２组，对照组（ｎ＝８）单纯吸氧（ＦｉＯ２，０４５），治疗组（ｎ＝９）吸氧（ＦｉＯ２，０４５）＋０００４５％（４５ｐｐｍ）ＮＯ，连续监测１２ｈ动脉血心肌酶谱变化。结果：治疗组乳酸脱氢酶（ＬＤＨ）、α－羟丁酸脱氢酶（α－ＨＢＤ）、肌酸激酶（ＣＫ）和天冬氨酸氨基转移酶（ＡＳＴ）均不同程度低于对照组（Ｐ＜００５，＜００１）。

Abstract AIM:To evaluates the effect of inhaled nitric oxide (NO) on myocardial enzyme spectrum in smoke inhalation injury. METHODS:After smoke inhalation injury, 17 dogs were divided radomly into 2 groups, control group ( n =8) given inhaled oxygen (FiO 2,0 45) and treated group ( n =9) given inhaled oxygen (FiO 2,0 45) mix with 0 0045% (45ppm) NO. Changes of myocardial enzyme spectrum in arterial blood were observed continuously for 12 hours. The data were analyzed using ANOVA for multiple mean comparisons. [WT5HZ] RESULTS:Lactic dehydrogenase (LDH),α-Hydroxybutyrate dehydrogenase (α-HBD) creatine kinase (CK) and aspartate aminotransferas (AST) of the treated group were lower than the control group ( P <0 05, P <0 01).CONCLUSION:Inhaled NO may decrease myocardial injury in smoke inhalation injury in dogs. MeSH Nitric oxid; Burn; Wounds and injuries; Myocardium; Enzymes