摘要
以3,4-二氯苯甲醛、对羟基苯甲醛,吡咯和1,5-二溴戊烷(或1,6-二溴己烷)为原料,经两步反应合成了溴烷氧基氯苯基卟啉(2a或2b);2与5-氟尿嘧啶反应,合成了两种新型的氯代苯基卟啉-5-氟尿嘧啶[1a(产率28.26%)和1b(产率29.34%)],其结构经UV-Vis,1H NMR,IR和MS表征。
Bromine-alkoxy-chlorophenyl porphyrin（2a or 2b） were synthesized by a two-step reaction from 3,4-dichlorobenzaldehyde, p-hydroxybenzaldehyde, pyrrole and 1,5-dibromopentane（ or 1,6-di- bromohexane）. Two new chlorophenyl porphyrin-5-fluorouracils were synthesized by the reaction of 2 with 5-fluorouracil. The yields reached 28.26% and 29.34%, respectively. Their structures were characterized by UV-Vis, 1H NMR, IR and MS.
出处
《合成化学》
CAS
CSCD
北大核心
2009年第6期699-701,共3页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(20601007)
河北省自然科学基金资助项目(203147)
河北省教育厅科学研究资助项目(2001120)
关键词
5-氟尿嘧啶
卟啉
合成
5-fluorouracil
porphyrin
synthesis
