取代四氢咪唑并[1,2-a]吡啶酮类化合物的合成

Synthesis of Substituted Tetrahydroimidazo[1,2-a] pyridone Compound

在三乙胺催化下,α-肉桂酰基烯酮二苄硫缩醛与乙二胺反应形成α-羰基-N,N-缩烯酮类化合物,其进一步发生分子内迈克尔加成反应,以中等产率合成了3个新型的取代四氢咪唑并[1,2-a]吡啶酮类化合物,其结构经1H NMR和IR表征。对反应机理进行了初步探讨。

α-Carbonyl-N, N-acetals were prepared via the reaction of α-cinnamoyl-dibenzyl-thioaeetals with ethylenediamine using triethylamine as the catalyst, Further, intramolecular Aza-Michael addition reactions occurred, and three new tetrahydroimidazo[ 1,2-α ] pyridone compounds in moderate yields were synthesized. A mechanism for this Aza-Michael addition reaction is proposed preliminarily.