微波法合成S-苄基半胱氨酰甘氨酸乙酯

Synthesis of S-benzylcysteinylglycine Ethyl Ester under Microwave Irradiation

微波条件下,溴化氢醋酸对S-苄基-N-苄氧羰基半胱氨酰甘氨酸乙酯(1)进行脱保护反应,合成了S-苄基半胱氨酰甘氨酸乙酯(2)。最佳反应条件为:12.9mmol,n(1)∶n(HBr-AcOH)=1∶6,微波功率200W,于30℃辐射20min,2的收率为87%。其结构经1H NMR和IR表征。

S-benzylcysteinylglycine ethyl ester（2） was synthesized by de-protect reaction of S-benzyl- N-benzyloxycarbonyl-cysteinylglycine ethyl ester （1） with HBr-AeOH under microwave irradiation. The structure was confirmed by 1H NMR and IR. The optimum reaction conditions at 30 ℃ for 20 rain were as follows ： 1 was 2.9 mmol ; n （ 1 ） ： n （ HBr-AcOH ） was 1 ： 6 ; power was 200 W. The yield of 2 was 87% under the conditions.