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连续腹膜透析老年终末期肾病患者血浆二甲基精氨酸与血管内皮功能损伤的关系 被引量:1

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摘要 终末期肾病(ESRD)患者发生心血管疾病(CVD)的危险性较同年龄、同性别的健康者高20倍。有研究资料显示,内皮功能障碍参与了CVD的发生发展。不对称性二甲基精氨酸(ADMA)是最重要的内源性一氧化氮合成酶(NOS)抑制剂,可以竞争性抑制NOS,使一氧化氮(NO)生成减少,导致心输出量降低、外周血管阻力增加及平均动脉压升高。
作者 康莉 夏天
出处 《中华老年医学杂志》 CAS CSCD 北大核心 2009年第11期944-945,共2页 Chinese Journal of Geriatrics
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