Ki-67抗原在膀胱癌中的表达及其意义

Expression and significance of Ki-67 antigen in bladder cancer

目的探讨Ki-67抗原在膀胱癌中的表达及其与膀胱癌分级、分期的关系。方法采用免疫组织化学法检测Ki-67抗原在60例膀胱癌患者和20例膀胱良性病变和10例正常膀胱黏膜中的表达。结果Ki-67抗原在60例膀胱癌标记指数为25．9％，在20例膀胱良性病变为103％，在10例正常膀胱黏膜中为1．1％，各组间差异有统计学意义；Ki-67抗原随着膀胱癌病理分级和临床分期的增加而表达升高。结论Ki-67抗原在膀胱癌细胞中表达升高并与膀胱癌分期、分级密切有关，Ki-67的表达可以作为评价细胞增生状态的指标，有可能成为判断肿瘤发生、发展、预后的重要指标。

Objective To investigate the expression of Ki-67 in bladder transitional cell carcinoma and its relationship with grade and stage. Methods Immunohistoehemistry method were used to detect the expression of Ki-67 in bladder transitional cell carcinoma and control groups. Results The positive expression rate of Ki-67 antigen in 60 cases of bladder cancer, 20 cases of benign bladder disease and 10 cases normal bladder mucosa were 25.9 %, 10.3 %0 and 1.1%. There were significantly difference among each group. The more grade and stage, the greater expression of Ki-67 antigen. Conclusion Ki-67 antigen is related to cell proliferation. The expression of the Ki-67 antigen in bladder cancer is closely related to the grade extent of tumor, and it is an important cell proliferation indicator. As a signal, Ki-67 antigen reflects cell proliferation, measurement of the expression of the Ki-67 antigen could reflect the condition of tumor cell proliferation. It might be an important prognostic factor for judging the occurrence, development and prognosis of the tumor.