血清唾液酸在恶性肿瘤中的临床应用价值

Study of serum sialic acid clinical significance in malignant tumor

目的探讨血清唾液酸（SA）在恶性肿瘤中的临床应用价值。方法采用酶法对50名健康人、90例良性疾病及160例恶性肿瘤患者血清SA的水平进行检测，分析血清SA水平在肿瘤不同病理类型及相关治疗前后的表达变化。结果恶性肿瘤各组血清SA水平均显著高于良性疾病组及健康对照组（P〈0．01），恶性肿瘤各组阳性率亦显著高于良性疾病组（P〈0．01）；各组织学类型恶性肿瘤组血清SA水平显著高于良性疾病组及健康对照组（P〈0．01），但各组织学类型恶性肿瘤组之间血清SA水平差异无统计学意义（P〉0．05）；恶性肿瘤患者经相关治疗后，病情好转组血清SA水平明显下降，与治疗前相比差异有统计学意义（P〈0．01）；病情恶化组血清SA水平有上升趋势，但与治疗前相比差异无统计学意义（P〉0．05）。结论血清SA对恶性肿瘤的诊断、治疗、疗效判断、病情监测及预后判断具有一定临床应用价值。

Objective To study the diagnosis value and clinical significance of serum sialic acid in malignant tumor. Methods Using enzymic method, the serum sialie acid levels were detected in 50 healthy persons, 90 benign disease patients, 160 malignant tumor patients. The serum sialic acid levels change were analyzed in different pathological types and after relative treatment. Results The serum sialic acid levels and positive ratio in malignant tumor groups were apparently higher than those in normal control and benign disease groups （P 〈0.01）. The serum sialic acid levels in malignant tumor of different pathological types were apparently higher than those in normal control and benign disease groups （P 〈0.01）, while there was no significance between different pathological types （P 〉0.05）. The serum sialic acid levels in the improved patients significantly dropped （P 〈0.01）, while those in the aggravated patients had an ascendent tendency. Conclusion The serum sialic acid has significant value in diagnosis, therapeutic effect and prognosis of malignant tumor.