病毒性心肌炎患儿血清IL-10、IL-18水平的变化及临床意义

目的探讨病毒性心肌炎(VM)患者血清白介素-10、IL-8水平的变化及其临床意义。方法采用双抗体夹心ELISA法检测47例VM(VM组)患者及39例健康对照组血清IL-10、IL-8的含量。结果VM组治疗前血清IL-10、IL-8水平均显著高于对照组(均P<0.01),VM组治疗4周后血清IL-10、IL-8水平均显著低于治疗前(均P<0.01)。结论炎性因子IL-10及IL一8可能在VM发病的免疫过程中发挥重要作用。

Oblective To explore the levels changes and clinical significance of serum interleukin-10（IL-10）.IL-8 in patients with viral myocarditis（VM）.Methods The levels of serum IL-10,IL-8 were detected by enzyme-linked immunosorbent assay（ELISA）in 47patients with VM（VM group）and 39healthy people as control group.Results The levels of serum IL-10,IL-8 were significantly higher in VM group before treatment compared with the control group（P〈0.01,respectively）.The levels Of serum IL-10and IL-8 after four-week treatment were significantly decreased than those before treatment in VM group（P〈0.01,respectively）.Conclusion Inflammatory cytokine IL-10 and IL-8.may play an important role in VM.