交质细胞在慢性疼痛中的病理及保护作用

The Pathology and protection of How Colloid Cell Effect during Chronic Soreness

目前认为，胶质细胞在病理性疼痛和慢性疼痛的发病机制中起了重要作用。胶质细胞受到激活后，星形胶质细胞和小胶质细胞都会做出反应，释放许多的信号分子。这些信号分子，或者具有保护作用，或者具有病理效应。在此，简单综述了胶质细胞对病理性疼痛的病理机制和其对神经元保护作用的基础。胶质细胞抗炎作用的保护性机制，已被作为研究新型神经病理性疼痛药物的靶点。考虑到目前慢性疼痛的普遍性和目前药物疗效的有限性。在新的关于胶质细胞——神经元细胞相互关系的理论指导下．研究和制定新的疼痛控制策略是值得的。

Now we believe Glia have been a key contributors to pathological and chronic pain mechanisms. When activation,both astrocytes and microglia respond to and release a number of signalling molecules,which have protective and/or pathological functions. Here we review the current understanding of the contribution of glia to pathological pain and neuroprotection,and how the protective anti-inflammatory actions of giia. Considering the prevalence of chronic pain and the partial efficacy of current drugs,new strategies to manipulate neuron-glia interactions in pain processing hold considerrable promise.